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KMID : 0356920070530050598
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Korean Journal of Anesthesiology
2007 Volume.53 No. 5 p.598 ~ p.601
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The Effect of Ondansetron on the Emergence Agitation after Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy
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Lee Kun-Moo
Kang Dong-Hwa
Lee Sang-Eun
Kim Young-Hwan
Lim Se-Hun
Lee Jeong-Han
Cheong Soon-Ho
Choe Young-Kyun
Kim Young-Jae
Shin Chee-Mahn
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Abstract
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Background: Emergence agitation is a common problem after sevoflurane anesthesia in children. Tropisetron, a 5-HT3 antagonist, significantly reduces the incidence of emergence agitation after sevoflurane anesthesia. This study evaluated the effect of ondansetron on emergence agitation after sevoflurane anesthesia in children undergoing a tonsillectomy.
Methods: Eighty children, aged 3?9 years (ASA physical status I) undergoing tonsillectomy, were randomly enrolled in this study. Group O received 0.1 mg/kg of ondansetron, and group S received 0.1 ml/kg of saline during the operation. Anesthesia was induced with 5 vol% sevoflurane and maintained with 2?2.5 vol% sevoflurane. The agitation score was recorded when they arrived at the postanesthesia care unit, and 10 minutes after that.
Results: The incidence of emergence agitation was 30% in group O and 27.5% in group S at arrival (P = 1.00). Ten minutes after arrival, the incidence was 12.5% in group O and 25% in group S (P = 0.25).
Conclusions: Ondansetron 0.1 mg/kg does not reduce the incidence of emergence agitation after sevoflurane in children. (Korean J Anesthesiol 2007; 53: 598∼601)
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KEYWORD
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emergence agitation, ondansetron, pediatric, sevoflurane
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